Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
| Uniprot primary ID | P47900 |
| PDB ID | 4XNV 1Y36 4XNW |
| DrugBank ID | |
| BioGrid ID | 111067 |
| GuidetoPHARMACOLOGY ID | 323 |
| PharmGKB ID | PA32868 |
| KEGG ID | hsa:5028 |
| DIP ID | |
| STRING ID | 9606.ENSP00000304767 |
| IntAct ID | P47900 |
| DMDM | 1352692 |
| BRENDA | |
| Reactome | R-HSA-417957 R-HSA-416476 R-HSA-418592 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5028 |
| BindingDB | P47900 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.846 | 0.008 | 0.982 | 0.003 | 0.914 | 0.007 | 0.906 | 0.005 | 0.971 | 0.003 | 0.833 | 0.008 | Download |
| Estate fingerprints | 0.817 | 0.005 | 0.869 | 0.008 | 0.843 | 0.007 | 0.841 | 0.009 | 0.914 | 0.005 | 0.691 | 0.012 | Download |
| MACCS fingerprints | 0.900 | 0.005 | 0.946 | 0.003 | 0.923 | 0.005 | 0.921 | 0.003 | 0.980 | 0.000 | 0.846 | 0.005 | Download |
| Daylight fingerprints | 0.822 | 0.008 | 0.956 | 0.006 | 0.889 | 0.006 | 0.881 | 0.006 | 0.952 | 0.004 | 0.784 | 0.010 | Download |
| ECFP2 fingerprints | 0.945 | 0.005 | 0.995 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.999 | 0.003 | 0.939 | 0.006 | Download |
| ECFP4 fingerprints | 0.967 | 0.005 | 0.993 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.962 | 0.004 | Download |
| ECFP6 fingerprints | 0.968 | 0.004 | 0.992 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.964 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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