TargetNet
  Target name

P48039: Melatonin receptor type 1A

  Protein function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

  Database links
Uniprot primary ID P48039
PDB ID
DrugBank ID DB06594 DB00980 DB09071 DB01065
BioGrid ID 110639
GuidetoPHARMACOLOGY ID 287
PharmGKB ID PA31267
KEGG ID hsa:4543
DIP ID
STRING ID 9606.ENSP00000302811
IntAct ID P48039
DMDM 1346544
BRENDA
Reactome R-HSA-418594 R-HSA-373076
SignaLink P48039
BioCyc
Entrez Gene (Gene ID) 4543
BindingDB P48039
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.943 0.005 0.921 0.003 0.932 0.004 0.932 0.004 0.978 0.004 0.868 0.004 Download
Estate fingerprints 0.935 0.008 0.853 0.005 0.894 0.007 0.896 0.005 0.962 0.004 0.788 0.010 Download
MACCS fingerprints 0.941 0.003 0.945 0.005 0.943 0.005 0.943 0.005 0.980 0.000 0.888 0.006 Download
Daylight fingerprints 0.719 0.003 0.817 0.003 0.768 0.004 0.752 0.004 0.840 0.000 0.534 0.007 Download
ECFP2 fingerprints 0.980 0.000 0.972 0.003 0.976 0.005 0.976 0.005 1.000 0.000 0.949 0.006 Download
ECFP4 fingerprints 0.987 0.005 0.981 0.004 0.984 0.005 0.984 0.005 1.000 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.980 0.000 0.996 0.000 0.988 0.004 0.988 0.004 1.000 0.000 0.970 0.000 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn