High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
| Uniprot primary ID | P48039 |
| PDB ID | |
| DrugBank ID | DB06594 DB00980 DB09071 DB01065 |
| BioGrid ID | 110639 |
| GuidetoPHARMACOLOGY ID | 287 |
| PharmGKB ID | PA31267 |
| KEGG ID | hsa:4543 |
| DIP ID | |
| STRING ID | 9606.ENSP00000302811 |
| IntAct ID | P48039 |
| DMDM | 1346544 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-373076 |
| SignaLink | P48039 |
| BioCyc | |
| Entrez Gene (Gene ID) | 4543 |
| BindingDB | P48039 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.943 | 0.005 | 0.921 | 0.003 | 0.932 | 0.004 | 0.932 | 0.004 | 0.978 | 0.004 | 0.868 | 0.004 | Download |
| Estate fingerprints | 0.935 | 0.008 | 0.853 | 0.005 | 0.894 | 0.007 | 0.896 | 0.005 | 0.962 | 0.004 | 0.788 | 0.010 | Download |
| MACCS fingerprints | 0.941 | 0.003 | 0.945 | 0.005 | 0.943 | 0.005 | 0.943 | 0.005 | 0.980 | 0.000 | 0.888 | 0.006 | Download |
| Daylight fingerprints | 0.719 | 0.003 | 0.817 | 0.003 | 0.768 | 0.004 | 0.752 | 0.004 | 0.840 | 0.000 | 0.534 | 0.007 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.972 | 0.003 | 0.976 | 0.005 | 0.976 | 0.005 | 1.000 | 0.000 | 0.949 | 0.006 | Download |
| ECFP4 fingerprints | 0.987 | 0.005 | 0.981 | 0.004 | 0.984 | 0.005 | 0.984 | 0.005 | 1.000 | 0.000 | 0.970 | 0.000 | Download |
| ECFP6 fingerprints | 0.980 | 0.000 | 0.996 | 0.000 | 0.988 | 0.004 | 0.988 | 0.004 | 1.000 | 0.000 | 0.970 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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