Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
| Uniprot primary ID | P48067 |
| PDB ID | |
| DrugBank ID | DB00145 |
| BioGrid ID | 112427 |
| GuidetoPHARMACOLOGY ID | 935 |
| PharmGKB ID | PA35916 |
| KEGG ID | hsa:6536 |
| DIP ID | |
| STRING ID | 9606.ENSP00000353791 |
| IntAct ID | P48067 |
| DMDM | 302393807 |
| BRENDA | |
| Reactome | R-HSA-442660 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 6536 |
| BindingDB | P48067 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.954 | 0.005 | 0.826 | 0.003 | 0.890 | 0.000 | 0.899 | 0.003 | 0.960 | 0.000 | 0.791 | 0.006 | Download |
| Estate fingerprints | 0.910 | 0.000 | 0.790 | 0.005 | 0.850 | 0.000 | 0.860 | 0.000 | 0.930 | 0.000 | 0.706 | 0.005 | Download |
| MACCS fingerprints | 0.797 | 0.005 | 0.863 | 0.004 | 0.830 | 0.000 | 0.823 | 0.005 | 0.920 | 0.000 | 0.658 | 0.006 | Download |
| Daylight fingerprints | 0.875 | 0.008 | 0.847 | 0.004 | 0.861 | 0.006 | 0.865 | 0.007 | 0.932 | 0.004 | 0.728 | 0.010 | Download |
| ECFP2 fingerprints | 0.960 | 0.000 | 0.960 | 0.003 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.920 | 0.000 | Download |
| ECFP4 fingerprints | 0.963 | 0.005 | 0.997 | 0.005 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.954 | 0.005 | Download |
| ECFP6 fingerprints | 0.940 | 0.000 | 0.998 | 0.000 | 0.969 | 0.003 | 0.965 | 0.005 | 0.990 | 0.000 | 0.932 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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