Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
| Uniprot primary ID | P48145 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 109092 |
| GuidetoPHARMACOLOGY ID | 303 |
| PharmGKB ID | PA28912 |
| KEGG ID | hsa:2831 |
| DIP ID | |
| STRING ID | 9606.ENSP00000330284 |
| IntAct ID | |
| DMDM | 215274092 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2831 |
| BindingDB | P48145 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.730 | 0.000 | 0.990 | 0.000 | 0.860 | 0.000 | 0.840 | 0.000 | 0.919 | 0.003 | 0.760 | 0.000 | Download |
| Estate fingerprints | 0.739 | 0.003 | 0.867 | 0.007 | 0.803 | 0.005 | 0.791 | 0.003 | 0.845 | 0.005 | 0.614 | 0.007 | Download |
| MACCS fingerprints | 0.757 | 0.007 | 0.963 | 0.005 | 0.860 | 0.000 | 0.845 | 0.005 | 0.891 | 0.003 | 0.735 | 0.005 | Download |
| Daylight fingerprints | 0.730 | 0.000 | 0.990 | 0.000 | 0.860 | 0.000 | 0.840 | 0.000 | 0.901 | 0.006 | 0.760 | 0.000 | Download |
| ECFP2 fingerprints | 0.841 | 0.010 | 0.985 | 0.008 | 0.913 | 0.005 | 0.908 | 0.006 | 0.932 | 0.004 | 0.839 | 0.010 | Download |
| ECFP4 fingerprints | 0.834 | 0.005 | 0.988 | 0.007 | 0.911 | 0.003 | 0.905 | 0.005 | 0.940 | 0.000 | 0.834 | 0.007 | Download |
| ECFP6 fingerprints | 0.830 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | 0.910 | 0.000 | 0.940 | 0.000 | 0.840 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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