Target name

P48147: Prolyl endopeptidase


  Protein function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

  Database links

Uniprot primary ID P48147
PDB ID 3DDU
DrugBank ID DB00107
BioGrid ID 111541
GuidetoPHARMACOLOGY ID 2395
PharmGKB ID PA33730
KEGG ID hsa:5550
DIP ID
STRING ID 9606.ENSP00000358106
IntAct ID P48147
DMDM 215273868
BRENDA 3.4.21.26
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 5550
BindingDB P48147

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.960 0.000 0.900 0.000 0.930 0.000 0.937 0.005 0.970 0.000 0.867 0.005 Download
Estate fingerprints 0.968 0.004 0.854 0.007 0.911 0.003 0.914 0.005 0.970 0.000 0.828 0.006 Download
MACCS fingerprints 0.966 0.007 0.938 0.009 0.952 0.004 0.952 0.004 0.974 0.005 0.904 0.007 Download
Daylight fingerprints 0.957 0.005 0.829 0.010 0.893 0.005 0.898 0.004 0.919 0.006 0.791 0.007 Download
ECFP2 fingerprints 0.980 0.000 0.960 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.948 0.004 Download
ECFP4 fingerprints 0.977 0.005 0.967 0.000 0.972 0.004 0.972 0.004 0.990 0.000 0.948 0.004 Download
ECFP6 fingerprints 0.970 0.000 0.986 0.000 0.978 0.004 0.978 0.004 0.990 0.000 0.954 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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