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E-mail: biomed@csu.edu.cn
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Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
| Uniprot primary ID | P48443 |
| PDB ID | 2GL8 |
| DrugBank ID | DB00523 DB00459 DB00755 DB00210 DB00307 |
| BioGrid ID | 112170 |
| GuidetoPHARMACOLOGY ID | 612 |
| PharmGKB ID | PA34892 |
| KEGG ID | |
| DIP ID | DIP-56220N |
| STRING ID | 9606.ENSP00000352900 |
| IntAct ID | P48443 |
| DMDM | 1350913 |
| BRENDA | |
| Reactome | R-HSA-383280 R-HSA-5362517 |
| SignaLink | P48443 |
| BioCyc | |
| Entrez Gene (Gene ID) | 6258 |
| BindingDB | P48443 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.943 | 0.007 | 0.971 | 0.006 | 0.957 | 0.007 | 0.957 | 0.007 | 0.992 | 0.004 | 0.915 | 0.007 | Download |
| Estate fingerprints | 0.988 | 0.004 | 0.968 | 0.000 | 0.978 | 0.004 | 0.978 | 0.004 | 0.990 | 0.000 | 0.958 | 0.004 | Download |
| MACCS fingerprints | 0.953 | 0.005 | 0.975 | 0.003 | 0.964 | 0.005 | 0.964 | 0.005 | 1.000 | 0.000 | 0.924 | 0.005 | Download |
| Daylight fingerprints | 0.875 | 0.011 | 0.897 | 0.010 | 0.886 | 0.007 | 0.886 | 0.007 | 0.946 | 0.005 | 0.777 | 0.015 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 1.000 | 0.005 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 0.997 | 0.005 | Download |
| ECFP4 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| ECFP6 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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