Target name

P48443: Retinoic acid receptor RXR-gamma


  Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

  Database links

Uniprot primary ID P48443
PDB ID 2GL8
DrugBank ID DB00523 DB00459 DB00755 DB00210 DB00307
BioGrid ID 112170
GuidetoPHARMACOLOGY ID 612
PharmGKB ID PA34892
KEGG ID
DIP ID DIP-56220N
STRING ID 9606.ENSP00000352900
IntAct ID P48443
DMDM 1350913
BRENDA
Reactome R-HSA-383280 R-HSA-5362517
SignaLink P48443
BioCyc
Entrez Gene (Gene ID) 6258
BindingDB P48443

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.943 0.007 0.971 0.006 0.957 0.007 0.957 0.007 0.992 0.004 0.915 0.007 Download
Estate fingerprints 0.988 0.004 0.968 0.000 0.978 0.004 0.978 0.004 0.990 0.000 0.958 0.004 Download
MACCS fingerprints 0.953 0.005 0.975 0.003 0.964 0.005 0.964 0.005 1.000 0.000 0.924 0.005 Download
Daylight fingerprints 0.875 0.011 0.897 0.010 0.886 0.007 0.886 0.007 0.946 0.005 0.777 0.015 Download
ECFP2 fingerprints 1.000 0.000 1.000 0.005 1.000 0.000 1.000 0.000 1.000 0.000 0.997 0.005 Download
ECFP4 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download
ECFP6 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn