Target name

P48736: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


  Protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

  Database links

Uniprot primary ID P48736
PDB ID 2A5U 3PRZ 3APD 3APF 3NZU 3QK0 3ENE 3L08 4FJZ 3TJP 2V4L 4G11 3IBE 4FUL 3PRE 4FHJ 3OAW 3QAQ 4FA6 3QJZ 4KZ0 3PS6 3QAR 1E8Z 3MJW 1E8Y 4WWP 4HVB 4EZL 4EZK 4EZJ 3SD5 1HE8 3S2A 4GB9 3CST 4FLH 4FHK 2A4Z 4XX5 4DK5 4PS7 4ANX 4ANW 4ANV 4KZC 3ZVV 3NZS 4HLE 4WWN 3T8M
DrugBank ID
BioGrid ID 111312
GuidetoPHARMACOLOGY ID 2156
PharmGKB ID PA33311
KEGG ID hsa:5294
DIP ID DIP-37781N
STRING ID 9606.ENSP00000352121
IntAct ID P48736
DMDM 92090623
BRENDA 2.7.1.137 2.7.1.153
Reactome R-HSA-1660499 R-HSA-114604 R-HSA-392451
SignaLink P48736
BioCyc MetaCyc:HS02818-MONOMER
Entrez Gene (Gene ID) 5294
BindingDB P48736

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.890 0.004 0.900 0.000 0.900 0.000 0.954 0.005 0.801 0.003 Download
Estate fingerprints 0.842 0.004 0.732 0.004 0.787 0.005 0.799 0.003 0.850 0.000 0.576 0.005 Download
MACCS fingerprints 0.870 0.000 0.788 0.005 0.829 0.003 0.833 0.005 0.910 0.000 0.657 0.005 Download
Daylight fingerprints 0.891 0.003 0.769 0.005 0.830 0.000 0.840 0.000 0.870 0.000 0.661 0.003 Download
ECFP2 fingerprints 0.960 0.000 0.890 0.005 0.925 0.005 0.928 0.004 0.980 0.000 0.851 0.006 Download
ECFP4 fingerprints 0.939 0.003 0.971 0.004 0.955 0.005 0.954 0.005 0.990 0.000 0.909 0.006 Download
ECFP6 fingerprints 0.906 0.005 0.974 0.000 0.940 0.000 0.940 0.000 0.984 0.005 0.890 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn