Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
| Uniprot primary ID | P49146 |
| PDB ID | 2IK3 |
| DrugBank ID | DB00847 |
| BioGrid ID | 110947 |
| GuidetoPHARMACOLOGY ID | 306 |
| PharmGKB ID | PA31741 |
| KEGG ID | hsa:4887 |
| DIP ID | |
| STRING ID | 9606.ENSP00000332591 |
| IntAct ID | P49146 |
| DMDM | 1352610 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 4887 |
| BindingDB | P49146 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.841 | 0.003 | 0.861 | 0.003 | 0.851 | 0.003 | 0.850 | 0.000 | 0.900 | 0.000 | 0.699 | 0.006 | Download |
| Estate fingerprints | 0.802 | 0.009 | 0.756 | 0.005 | 0.779 | 0.006 | 0.784 | 0.005 | 0.850 | 0.000 | 0.558 | 0.008 | Download |
| MACCS fingerprints | 0.791 | 0.007 | 0.837 | 0.007 | 0.814 | 0.005 | 0.809 | 0.006 | 0.871 | 0.003 | 0.629 | 0.010 | Download |
| Daylight fingerprints | 0.817 | 0.013 | 0.923 | 0.000 | 0.870 | 0.007 | 0.862 | 0.008 | 0.890 | 0.000 | 0.745 | 0.013 | Download |
| ECFP2 fingerprints | 0.827 | 0.005 | 0.947 | 0.005 | 0.887 | 0.005 | 0.879 | 0.003 | 0.920 | 0.000 | 0.777 | 0.005 | Download |
| ECFP4 fingerprints | 0.848 | 0.004 | 0.960 | 0.000 | 0.904 | 0.005 | 0.900 | 0.000 | 0.933 | 0.005 | 0.817 | 0.005 | Download |
| ECFP6 fingerprints | 0.813 | 0.005 | 0.983 | 0.000 | 0.898 | 0.004 | 0.888 | 0.004 | 0.940 | 0.000 | 0.806 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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