Target name

P49146: Neuropeptide Y receptor type 2


  Protein function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

  Database links

Uniprot primary ID P49146
PDB ID 2IK3
DrugBank ID DB00847
BioGrid ID 110947
GuidetoPHARMACOLOGY ID 306
PharmGKB ID PA31741
KEGG ID hsa:4887
DIP ID
STRING ID 9606.ENSP00000332591
IntAct ID P49146
DMDM 1352610
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4887
BindingDB P49146

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.841 0.003 0.861 0.003 0.851 0.003 0.850 0.000 0.900 0.000 0.699 0.006 Download
Estate fingerprints 0.802 0.009 0.756 0.005 0.779 0.006 0.784 0.005 0.850 0.000 0.558 0.008 Download
MACCS fingerprints 0.791 0.007 0.837 0.007 0.814 0.005 0.809 0.006 0.871 0.003 0.629 0.010 Download
Daylight fingerprints 0.817 0.013 0.923 0.000 0.870 0.007 0.862 0.008 0.890 0.000 0.745 0.013 Download
ECFP2 fingerprints 0.827 0.005 0.947 0.005 0.887 0.005 0.879 0.003 0.920 0.000 0.777 0.005 Download
ECFP4 fingerprints 0.848 0.004 0.960 0.000 0.904 0.005 0.900 0.000 0.933 0.005 0.817 0.005 Download
ECFP6 fingerprints 0.813 0.005 0.983 0.000 0.898 0.004 0.888 0.004 0.940 0.000 0.806 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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