High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
| Uniprot primary ID | P49286 |
| PDB ID | |
| DrugBank ID | DB06594 DB00980 DB09071 DB01065 |
| BioGrid ID | 110640 |
| GuidetoPHARMACOLOGY ID | 288 |
| PharmGKB ID | PA31268 |
| KEGG ID | hsa:4544 |
| DIP ID | |
| STRING ID | 9606.ENSP00000257068 |
| IntAct ID | P49286 |
| DMDM | 1346548 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-373076 |
| SignaLink | P49286 |
| BioCyc | |
| Entrez Gene (Gene ID) | 4544 |
| BindingDB | P49286 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.936 | 0.005 | 0.902 | 0.006 | 0.919 | 0.003 | 0.920 | 0.000 | 0.973 | 0.005 | 0.840 | 0.005 | Download |
| Estate fingerprints | 0.930 | 0.000 | 0.890 | 0.000 | 0.910 | 0.000 | 0.910 | 0.000 | 0.970 | 0.000 | 0.815 | 0.005 | Download |
| MACCS fingerprints | 0.942 | 0.004 | 0.938 | 0.003 | 0.940 | 0.000 | 0.940 | 0.000 | 0.980 | 0.000 | 0.887 | 0.005 | Download |
| Daylight fingerprints | 0.721 | 0.003 | 0.815 | 0.000 | 0.768 | 0.004 | 0.754 | 0.005 | 0.849 | 0.003 | 0.534 | 0.005 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.960 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.999 | 0.003 | 0.975 | 0.005 | Download |
| ECFP6 fingerprints | 0.980 | 0.000 | 0.998 | 0.004 | 0.989 | 0.003 | 0.989 | 0.003 | 0.990 | 0.000 | 0.971 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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