TargetNet
  Target name

P49286: Melatonin receptor type 1B

  Protein function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

  Database links
Uniprot primary ID P49286
PDB ID
DrugBank ID DB06594 DB00980 DB09071 DB01065
BioGrid ID 110640
GuidetoPHARMACOLOGY ID 288
PharmGKB ID PA31268
KEGG ID hsa:4544
DIP ID
STRING ID 9606.ENSP00000257068
IntAct ID P49286
DMDM 1346548
BRENDA
Reactome R-HSA-418594 R-HSA-373076
SignaLink P49286
BioCyc
Entrez Gene (Gene ID) 4544
BindingDB P49286
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.936 0.005 0.902 0.006 0.919 0.003 0.920 0.000 0.973 0.005 0.840 0.005 Download
Estate fingerprints 0.930 0.000 0.890 0.000 0.910 0.000 0.910 0.000 0.970 0.000 0.815 0.005 Download
MACCS fingerprints 0.942 0.004 0.938 0.003 0.940 0.000 0.940 0.000 0.980 0.000 0.887 0.005 Download
Daylight fingerprints 0.721 0.003 0.815 0.000 0.768 0.004 0.754 0.005 0.849 0.003 0.534 0.005 Download
ECFP2 fingerprints 0.980 0.000 0.960 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.000 0.990 0.000 0.990 0.000 0.999 0.003 0.975 0.005 Download
ECFP6 fingerprints 0.980 0.000 0.998 0.004 0.989 0.003 0.989 0.003 0.990 0.000 0.971 0.003 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn