Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (By similarity).
| Uniprot primary ID | P49355 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | bta:327686 |
| DIP ID | |
| STRING ID | 9913.ENSBTAP00000007751 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-BTA-2514859 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 327686 |
| BindingDB | P49355 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.780 | 0.000 | 0.980 | 0.000 | 0.880 | 0.000 | 0.870 | 0.000 | 0.960 | 0.000 | 0.781 | 0.003 | Download |
| Estate fingerprints | 0.631 | 0.003 | 0.875 | 0.006 | 0.753 | 0.005 | 0.721 | 0.006 | 0.870 | 0.000 | 0.525 | 0.007 | Download |
| MACCS fingerprints | 0.720 | 0.005 | 0.904 | 0.007 | 0.812 | 0.004 | 0.794 | 0.005 | 0.910 | 0.000 | 0.639 | 0.006 | Download |
| Daylight fingerprints | 0.713 | 0.005 | 1.000 | 0.000 | 0.858 | 0.004 | 0.832 | 0.004 | 0.943 | 0.007 | 0.745 | 0.005 | Download |
| ECFP2 fingerprints | 0.945 | 0.007 | 0.987 | 0.005 | 0.966 | 0.005 | 0.964 | 0.005 | 0.990 | 0.000 | 0.930 | 0.005 | Download |
| ECFP4 fingerprints | 0.910 | 0.011 | 0.996 | 0.000 | 0.953 | 0.007 | 0.952 | 0.006 | 0.992 | 0.004 | 0.909 | 0.010 | Download |
| ECFP6 fingerprints | 0.874 | 0.007 | 0.994 | 0.000 | 0.934 | 0.005 | 0.929 | 0.003 | 0.993 | 0.005 | 0.874 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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