Target name

P49355: Protein farnesyltransferase subunit beta


  Protein function

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (By similarity).

  Database links

Uniprot primary ID P49355
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:327686
DIP ID
STRING ID 9913.ENSBTAP00000007751
IntAct ID
DMDM
BRENDA
Reactome R-BTA-2514859
SignaLink
BioCyc
Entrez Gene (Gene ID) 327686
BindingDB P49355

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.780 0.000 0.980 0.000 0.880 0.000 0.870 0.000 0.960 0.000 0.781 0.003 Download
Estate fingerprints 0.631 0.003 0.875 0.006 0.753 0.005 0.721 0.006 0.870 0.000 0.525 0.007 Download
MACCS fingerprints 0.720 0.005 0.904 0.007 0.812 0.004 0.794 0.005 0.910 0.000 0.639 0.006 Download
Daylight fingerprints 0.713 0.005 1.000 0.000 0.858 0.004 0.832 0.004 0.943 0.007 0.745 0.005 Download
ECFP2 fingerprints 0.945 0.007 0.987 0.005 0.966 0.005 0.964 0.005 0.990 0.000 0.930 0.005 Download
ECFP4 fingerprints 0.910 0.011 0.996 0.000 0.953 0.007 0.952 0.006 0.992 0.004 0.909 0.010 Download
ECFP6 fingerprints 0.874 0.007 0.994 0.000 0.934 0.005 0.929 0.003 0.993 0.005 0.874 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn