Target name

P49356: Protein farnesyltransferase subunit beta


  Protein function

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

  Database links

Uniprot primary ID P49356
PDB ID 1TN6 2IEJ 2H6F 1MZC 2H6H 2H6I 2H6G 3E37 1JCQ 1SA4 1S63 1LD8 1LD7 2F0Y
DrugBank ID
BioGrid ID 108627
GuidetoPHARMACOLOGY ID 2826
PharmGKB ID PA28202
KEGG ID hsa:2342 hsa:100529261
DIP ID
STRING ID 9606.ENSP00000246166
IntAct ID P49356
DMDM 1346696
BRENDA
Reactome R-HSA-2514859
SignaLink
BioCyc
Entrez Gene (Gene ID) 2342;100529261
BindingDB P49356

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.880 0.000 0.962 0.000 0.921 0.003 0.920 0.000 0.970 0.000 0.850 0.000 Download
Estate fingerprints 0.764 0.005 0.856 0.000 0.810 0.000 0.801 0.003 0.900 0.000 0.627 0.005 Download
MACCS fingerprints 0.790 0.000 0.746 0.005 0.768 0.004 0.770 0.000 0.860 0.000 0.533 0.005 Download
Daylight fingerprints 0.822 0.004 0.878 0.003 0.850 0.000 0.849 0.003 0.880 0.000 0.703 0.005 Download
ECFP2 fingerprints 0.950 0.000 0.970 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.919 0.003 Download
ECFP4 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP6 fingerprints 0.930 0.000 0.990 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.927 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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