Target name

P49759: Dual specificity protein kinase CLK1


  Protein function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

  Database links

Uniprot primary ID P49759
PDB ID 2VAG 1Z57
DrugBank ID
BioGrid ID 107606
GuidetoPHARMACOLOGY ID 1990
PharmGKB ID PA26594
KEGG ID hsa:1195
DIP ID
STRING ID 9606.ENSP00000394734
IntAct ID P49759
DMDM 206729857
BRENDA 2.7.12.1
Reactome
SignaLink P49759
BioCyc
Entrez Gene (Gene ID) 1195
BindingDB P49759

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.752 0.004 0.896 0.012 0.824 0.005 0.811 0.007 0.891 0.003 0.655 0.014 Download
Estate fingerprints 0.723 0.005 0.793 0.003 0.758 0.004 0.748 0.004 0.830 0.000 0.513 0.007 Download
MACCS fingerprints 0.723 0.005 0.801 0.004 0.762 0.004 0.752 0.004 0.853 0.005 0.524 0.010 Download
Daylight fingerprints 0.690 0.005 0.930 0.005 0.810 0.007 0.787 0.005 0.888 0.004 0.644 0.013 Download
ECFP2 fingerprints 0.789 0.017 0.803 0.011 0.796 0.007 0.793 0.009 0.903 0.005 0.587 0.016 Download
ECFP4 fingerprints 0.733 0.011 0.879 0.007 0.806 0.005 0.792 0.008 0.907 0.005 0.622 0.012 Download
ECFP6 fingerprints 0.700 0.011 0.918 0.004 0.809 0.009 0.784 0.007 0.908 0.004 0.630 0.015 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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