Target name

P49768: Presenilin-1


  Protein function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

  Database links

Uniprot primary ID P49768
PDB ID 4UIS 5A63 2KR6
DrugBank ID
BioGrid ID 111642
GuidetoPHARMACOLOGY ID 2402
PharmGKB ID PA33855
KEGG ID hsa:5663
DIP ID DIP-1134N
STRING ID 9606.ENSP00000326366
IntAct ID P49768
DMDM 1709856
BRENDA
Reactome R-HSA-1474228
SignaLink P49768
BioCyc
Entrez Gene (Gene ID) 5663
BindingDB P49768

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.877 0.005 0.949 0.000 0.913 0.005 0.909 0.003 0.979 0.003 0.832 0.006 Download
Estate fingerprints 0.899 0.007 0.833 0.003 0.866 0.005 0.868 0.006 0.950 0.000 0.731 0.012 Download
MACCS fingerprints 0.800 0.000 0.860 0.003 0.830 0.000 0.820 0.000 0.928 0.004 0.659 0.003 Download
Daylight fingerprints 0.802 0.006 0.976 0.000 0.889 0.003 0.879 0.003 0.943 0.005 0.795 0.007 Download
ECFP2 fingerprints 0.982 0.009 0.954 0.005 0.968 0.006 0.968 0.006 1.000 0.000 0.941 0.009 Download
ECFP4 fingerprints 0.966 0.005 0.984 0.003 0.975 0.005 0.975 0.005 1.000 0.000 0.950 0.000 Download
ECFP6 fingerprints 0.955 0.005 0.993 0.000 0.974 0.005 0.974 0.005 1.000 0.000 0.947 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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