Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
| Uniprot primary ID | P49810 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 111643 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33856 |
| KEGG ID | hsa:5664 |
| DIP ID | |
| STRING ID | 9606.ENSP00000355747 |
| IntAct ID | P49810 |
| DMDM | 1709858 |
| BRENDA | |
| Reactome | R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096 |
| SignaLink | P49810 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5664 |
| BindingDB | P49810 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.952 | 0.008 | 0.926 | 0.004 | 0.939 | 0.006 | 0.939 | 0.006 | 0.984 | 0.005 | 0.878 | 0.008 | Download |
| Estate fingerprints | 0.965 | 0.005 | 0.855 | 0.005 | 0.910 | 0.000 | 0.915 | 0.005 | 0.968 | 0.004 | 0.825 | 0.005 | Download |
| MACCS fingerprints | 0.693 | 0.007 | 0.869 | 0.003 | 0.781 | 0.006 | 0.761 | 0.006 | 0.929 | 0.003 | 0.574 | 0.008 | Download |
| Daylight fingerprints | 0.888 | 0.004 | 0.976 | 0.004 | 0.932 | 0.004 | 0.930 | 0.000 | 0.960 | 0.000 | 0.867 | 0.005 | Download |
| ECFP2 fingerprints | 0.996 | 0.005 | 0.982 | 0.005 | 0.989 | 0.003 | 0.989 | 0.003 | 0.991 | 0.003 | 0.973 | 0.005 | Download |
| ECFP4 fingerprints | 0.977 | 0.005 | 0.981 | 0.003 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.956 | 0.007 | Download |
| ECFP6 fingerprints | 0.974 | 0.005 | 0.994 | 0.000 | 0.984 | 0.005 | 0.984 | 0.005 | 1.000 | 0.000 | 0.970 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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