Target name

P49810: Presenilin-2


  Protein function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

  Database links

Uniprot primary ID P49810
PDB ID
DrugBank ID
BioGrid ID 111643
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33856
KEGG ID hsa:5664
DIP ID
STRING ID 9606.ENSP00000355747
IntAct ID P49810
DMDM 1709858
BRENDA
Reactome R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink P49810
BioCyc
Entrez Gene (Gene ID) 5664
BindingDB P49810

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.952 0.008 0.926 0.004 0.939 0.006 0.939 0.006 0.984 0.005 0.878 0.008 Download
Estate fingerprints 0.965 0.005 0.855 0.005 0.910 0.000 0.915 0.005 0.968 0.004 0.825 0.005 Download
MACCS fingerprints 0.693 0.007 0.869 0.003 0.781 0.006 0.761 0.006 0.929 0.003 0.574 0.008 Download
Daylight fingerprints 0.888 0.004 0.976 0.004 0.932 0.004 0.930 0.000 0.960 0.000 0.867 0.005 Download
ECFP2 fingerprints 0.996 0.005 0.982 0.005 0.989 0.003 0.989 0.003 0.991 0.003 0.973 0.005 Download
ECFP4 fingerprints 0.977 0.005 0.981 0.003 0.979 0.003 0.979 0.003 1.000 0.000 0.956 0.007 Download
ECFP6 fingerprints 0.974 0.005 0.994 0.000 0.984 0.005 0.984 0.005 1.000 0.000 0.970 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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