Target name

P49840: Glycogen synthase kinase-3 alpha


  Protein function

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

  Database links

Uniprot primary ID P49840
PDB ID 2DFM
DrugBank ID
BioGrid ID 109186
GuidetoPHARMACOLOGY ID 2029
PharmGKB ID PA29008
KEGG ID hsa:2931
DIP ID
STRING ID 9606.ENSP00000222330
IntAct ID P49840
DMDM 12644292
BRENDA
Reactome R-HSA-5674400 R-HSA-381038 R-HSA-198323
SignaLink P49840
BioCyc
Entrez Gene (Gene ID) 2931
BindingDB P49840

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.833 0.007 0.957 0.006 0.895 0.005 0.890 0.000 0.950 0.000 0.796 0.007 Download
Estate fingerprints 0.790 0.005 0.758 0.003 0.774 0.005 0.775 0.005 0.868 0.004 0.547 0.008 Download
MACCS fingerprints 0.811 0.007 0.879 0.007 0.845 0.005 0.839 0.003 0.920 0.000 0.688 0.009 Download
Daylight fingerprints 0.642 0.004 0.998 0.000 0.820 0.000 0.780 0.000 0.945 0.005 0.682 0.004 Download
ECFP2 fingerprints 0.912 0.004 0.902 0.005 0.907 0.005 0.907 0.005 0.968 0.004 0.811 0.003 Download
ECFP4 fingerprints 0.911 0.003 0.969 0.004 0.940 0.005 0.940 0.005 0.970 0.000 0.882 0.008 Download
ECFP6 fingerprints 0.898 0.004 0.982 0.000 0.940 0.000 0.938 0.004 0.970 0.000 0.880 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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