Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
| Uniprot primary ID | P50052 |
| PDB ID | |
| DrugBank ID | DB01349 |
| BioGrid ID | 106692 |
| GuidetoPHARMACOLOGY ID | 35 |
| PharmGKB ID | PA44 |
| KEGG ID | hsa:186 |
| DIP ID | |
| STRING ID | 9606.ENSP00000360973 |
| IntAct ID | P50052 |
| DMDM | 1703214 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 186 |
| BindingDB | P50052 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.818 | 0.004 | 0.998 | 0.000 | 0.908 | 0.004 | 0.898 | 0.004 | 0.990 | 0.000 | 0.828 | 0.004 | Download |
| Estate fingerprints | 0.822 | 0.006 | 0.848 | 0.005 | 0.835 | 0.005 | 0.834 | 0.005 | 0.920 | 0.000 | 0.670 | 0.008 | Download |
| MACCS fingerprints | 0.776 | 0.005 | 0.872 | 0.003 | 0.824 | 0.005 | 0.816 | 0.005 | 0.920 | 0.000 | 0.651 | 0.007 | Download |
| Daylight fingerprints | 0.849 | 0.003 | 0.911 | 0.000 | 0.880 | 0.000 | 0.875 | 0.005 | 0.930 | 0.000 | 0.759 | 0.003 | Download |
| ECFP2 fingerprints | 0.919 | 0.006 | 0.981 | 0.000 | 0.950 | 0.000 | 0.947 | 0.005 | 0.990 | 0.000 | 0.903 | 0.005 | Download |
| ECFP4 fingerprints | 0.914 | 0.005 | 0.986 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 1.000 | 0.000 | 0.910 | 0.000 | Download |
| ECFP6 fingerprints | 0.887 | 0.005 | 0.993 | 0.000 | 0.940 | 0.000 | 0.938 | 0.004 | 1.000 | 0.000 | 0.885 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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