Target name

P50172: Corticosteroid 11-beta-dehydrogenase isozyme 1


  Protein function

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

  Database links

Uniprot primary ID P50172
PDB ID 1Y5M 1Y5R 4NMH 3GMD 4K26
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:15483
DIP ID
STRING ID 10090.ENSMUSP00000016338
IntAct ID P50172
DMDM
BRENDA 1.1.1.146
Reactome R-MMU-194002
SignaLink
BioCyc
Entrez Gene (Gene ID) 15483
BindingDB P50172

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.819 0.003 0.901 0.005 0.860 0.000 0.857 0.005 0.940 0.000 0.727 0.005 Download
Estate fingerprints 0.840 0.005 0.834 0.003 0.837 0.005 0.837 0.005 0.901 0.003 0.669 0.009 Download
MACCS fingerprints 0.706 0.005 0.838 0.003 0.772 0.004 0.757 0.005 0.860 0.000 0.550 0.007 Download
Daylight fingerprints 0.793 0.005 0.945 0.005 0.869 0.003 0.859 0.003 0.949 0.003 0.750 0.008 Download
ECFP2 fingerprints 0.949 0.003 0.937 0.000 0.943 0.005 0.944 0.005 0.980 0.000 0.888 0.004 Download
ECFP4 fingerprints 0.946 0.005 0.974 0.000 0.960 0.000 0.958 0.004 0.980 0.000 0.916 0.005 Download
ECFP6 fingerprints 0.929 0.003 0.971 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.908 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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