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Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
| Uniprot primary ID | P50579 |
| PDB ID | 2GA2 1R5G 2OAZ 1YW9 1BN5 1YW8 1YW7 1QZY 1B6A 1R5H 1B59 1BOA 2ADU 1R58 1KQ9 2EA4 2EA2 1KQ0 |
| DrugBank ID | DB00134 DB01422 |
| BioGrid ID | 116184 |
| GuidetoPHARMACOLOGY ID | 1573 |
| PharmGKB ID | PA30765 |
| KEGG ID | hsa:10988 |
| DIP ID | |
| STRING ID | 9606.ENSP00000325312 |
| IntAct ID | P50579 |
| DMDM | 1703273 |
| BRENDA | 3.4.11.18 |
| Reactome | R-HSA-2514859 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 10988 |
| BindingDB | P50579 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.859 | 0.007 | 0.967 | 0.005 | 0.913 | 0.005 | 0.906 | 0.005 | 0.980 | 0.000 | 0.829 | 0.009 | Download |
| Estate fingerprints | 0.887 | 0.007 | 0.811 | 0.004 | 0.849 | 0.006 | 0.854 | 0.005 | 0.920 | 0.000 | 0.698 | 0.010 | Download |
| MACCS fingerprints | 0.825 | 0.010 | 0.833 | 0.003 | 0.829 | 0.006 | 0.829 | 0.006 | 0.920 | 0.000 | 0.659 | 0.007 | Download |
| Daylight fingerprints | 0.880 | 0.000 | 0.860 | 0.000 | 0.870 | 0.000 | 0.870 | 0.000 | 0.910 | 0.000 | 0.740 | 0.000 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.970 | 0.005 | 0.975 | 0.005 | 0.975 | 0.005 | 1.000 | 0.000 | 0.948 | 0.004 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.003 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP6 fingerprints | 0.956 | 0.005 | 1.000 | 0.000 | 0.980 | 0.000 | 0.979 | 0.003 | 1.000 | 0.000 | 0.956 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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