Target name

P50579: Methionine aminopeptidase 2


  Protein function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.

  Database links

Uniprot primary ID P50579
PDB ID 2GA2 1R5G 2OAZ 1YW9 1BN5 1YW8 1YW7 1QZY 1B6A 1R5H 1B59 1BOA 2ADU 1R58 1KQ9 2EA4 2EA2 1KQ0
DrugBank ID DB00134 DB01422
BioGrid ID 116184
GuidetoPHARMACOLOGY ID 1573
PharmGKB ID PA30765
KEGG ID hsa:10988
DIP ID
STRING ID 9606.ENSP00000325312
IntAct ID P50579
DMDM 1703273
BRENDA 3.4.11.18
Reactome R-HSA-2514859
SignaLink
BioCyc
Entrez Gene (Gene ID) 10988
BindingDB P50579

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.859 0.007 0.967 0.005 0.913 0.005 0.906 0.005 0.980 0.000 0.829 0.009 Download
Estate fingerprints 0.887 0.007 0.811 0.004 0.849 0.006 0.854 0.005 0.920 0.000 0.698 0.010 Download
MACCS fingerprints 0.825 0.010 0.833 0.003 0.829 0.006 0.829 0.006 0.920 0.000 0.659 0.007 Download
Daylight fingerprints 0.880 0.000 0.860 0.000 0.870 0.000 0.870 0.000 0.910 0.000 0.740 0.000 Download
ECFP2 fingerprints 0.980 0.000 0.970 0.005 0.975 0.005 0.975 0.005 1.000 0.000 0.948 0.004 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.003 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP6 fingerprints 0.956 0.005 1.000 0.000 0.980 0.000 0.979 0.003 1.000 0.000 0.956 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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