Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
| Uniprot primary ID | P51639 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 247704 |
| GuidetoPHARMACOLOGY ID | 639 |
| PharmGKB ID | |
| KEGG ID | rno:25675 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000022055 |
| IntAct ID | |
| DMDM | |
| BRENDA | 1.1.1.34 |
| Reactome | R-RNO-191273 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25675 |
| BindingDB | P51639 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | Download |
| Estate fingerprints | 0.999 | 0.003 | 0.939 | 0.005 | 0.969 | 0.003 | 0.970 | 0.000 | 1.000 | 0.000 | 0.936 | 0.005 | Download |
| MACCS fingerprints | 0.962 | 0.004 | 0.958 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.924 | 0.005 | Download |
| Daylight fingerprints | 0.882 | 0.004 | 0.978 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.970 | 0.000 | 0.862 | 0.004 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| ECFP4 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| ECFP6 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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