Target name

P51639: 3-hydroxy-3-methylglutaryl-coenzyme A reductase


  Protein function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

  Database links

Uniprot primary ID P51639
PDB ID
DrugBank ID
BioGrid ID 247704
GuidetoPHARMACOLOGY ID 639
PharmGKB ID
KEGG ID rno:25675
DIP ID
STRING ID 10116.ENSRNOP00000022055
IntAct ID
DMDM
BRENDA 1.1.1.34
Reactome R-RNO-191273
SignaLink
BioCyc
Entrez Gene (Gene ID) 25675
BindingDB P51639

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 0.990 0.000 Download
Estate fingerprints 0.999 0.003 0.939 0.005 0.969 0.003 0.970 0.000 1.000 0.000 0.936 0.005 Download
MACCS fingerprints 0.962 0.004 0.958 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.924 0.005 Download
Daylight fingerprints 0.882 0.004 0.978 0.005 0.930 0.000 0.930 0.000 0.970 0.000 0.862 0.004 Download
ECFP2 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download
ECFP4 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download
ECFP6 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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