Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
| Uniprot primary ID | P51661 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | mmu:15484 |
| DIP ID | |
| STRING ID | 10090.ENSMUSP00000034363 |
| IntAct ID | P51661 |
| DMDM | |
| BRENDA | 1.1.1.146 1.1.1.B40 |
| Reactome | R-MMU-194002 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 15484 |
| BindingDB | P51661 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.910 | 0.000 | 0.990 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.980 | 0.000 | 0.900 | 0.000 | Download |
| Estate fingerprints | 0.910 | 0.000 | 0.960 | 0.005 | 0.935 | 0.005 | 0.935 | 0.005 | 0.980 | 0.000 | 0.875 | 0.005 | Download |
| MACCS fingerprints | 0.910 | 0.000 | 0.950 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.950 | 0.000 | 0.860 | 0.000 | Download |
| Daylight fingerprints | 0.881 | 0.003 | 0.999 | 0.000 | 0.940 | 0.000 | 0.939 | 0.003 | 0.961 | 0.003 | 0.889 | 0.003 | Download |
| ECFP2 fingerprints | 0.966 | 0.007 | 0.988 | 0.005 | 0.977 | 0.005 | 0.972 | 0.004 | 1.000 | 0.000 | 0.948 | 0.006 | Download |
| ECFP4 fingerprints | 0.978 | 0.004 | 0.982 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.967 | 0.005 | Download |
| ECFP6 fingerprints | 0.963 | 0.005 | 0.997 | 0.000 | 0.980 | 0.000 | 0.979 | 0.003 | 0.990 | 0.000 | 0.959 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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