Target name

P51661: Corticosteroid 11-beta-dehydrogenase isozyme 2


  Protein function

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

  Database links

Uniprot primary ID P51661
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:15484
DIP ID
STRING ID 10090.ENSMUSP00000034363
IntAct ID P51661
DMDM
BRENDA 1.1.1.146 1.1.1.B40
Reactome R-MMU-194002
SignaLink
BioCyc
Entrez Gene (Gene ID) 15484
BindingDB P51661

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.990 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.900 0.000 Download
Estate fingerprints 0.910 0.000 0.960 0.005 0.935 0.005 0.935 0.005 0.980 0.000 0.875 0.005 Download
MACCS fingerprints 0.910 0.000 0.950 0.005 0.930 0.000 0.930 0.000 0.950 0.000 0.860 0.000 Download
Daylight fingerprints 0.881 0.003 0.999 0.000 0.940 0.000 0.939 0.003 0.961 0.003 0.889 0.003 Download
ECFP2 fingerprints 0.966 0.007 0.988 0.005 0.977 0.005 0.972 0.004 1.000 0.000 0.948 0.006 Download
ECFP4 fingerprints 0.978 0.004 0.982 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.967 0.005 Download
ECFP6 fingerprints 0.963 0.005 0.997 0.000 0.980 0.000 0.979 0.003 0.990 0.000 0.959 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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