Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
| Uniprot primary ID | P51677 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 107637 |
| GuidetoPHARMACOLOGY ID | 60 |
| PharmGKB ID | PA26168 |
| KEGG ID | |
| DIP ID | DIP-5846N |
| STRING ID | 9606.ENSP00000441600 |
| IntAct ID | P51677 |
| DMDM | 1705892 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-380108 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1232 |
| BindingDB | P51677 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.915 | 0.005 | 0.867 | 0.003 | 0.891 | 0.003 | 0.892 | 0.004 | 0.950 | 0.000 | 0.782 | 0.004 | Download |
| Estate fingerprints | 0.873 | 0.005 | 0.767 | 0.004 | 0.820 | 0.000 | 0.830 | 0.000 | 0.900 | 0.000 | 0.643 | 0.005 | Download |
| MACCS fingerprints | 0.864 | 0.005 | 0.816 | 0.005 | 0.840 | 0.000 | 0.845 | 0.005 | 0.920 | 0.000 | 0.682 | 0.004 | Download |
| Daylight fingerprints | 0.878 | 0.004 | 0.782 | 0.004 | 0.830 | 0.000 | 0.840 | 0.000 | 0.861 | 0.003 | 0.670 | 0.000 | Download |
| ECFP2 fingerprints | 0.894 | 0.005 | 0.932 | 0.005 | 0.913 | 0.005 | 0.910 | 0.000 | 0.980 | 0.000 | 0.830 | 0.000 | Download |
| ECFP4 fingerprints | 0.910 | 0.000 | 0.974 | 0.004 | 0.942 | 0.004 | 0.940 | 0.000 | 0.990 | 0.000 | 0.890 | 0.000 | Download |
| ECFP6 fingerprints | 0.902 | 0.004 | 0.994 | 0.000 | 0.948 | 0.004 | 0.941 | 0.003 | 0.990 | 0.000 | 0.894 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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