Target name

P51677: C-C chemokine receptor type 3


  Protein function

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

  Database links

Uniprot primary ID P51677
PDB ID
DrugBank ID
BioGrid ID 107637
GuidetoPHARMACOLOGY ID 60
PharmGKB ID PA26168
KEGG ID
DIP ID DIP-5846N
STRING ID 9606.ENSP00000441600
IntAct ID P51677
DMDM 1705892
BRENDA
Reactome R-HSA-418594 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID) 1232
BindingDB P51677

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.915 0.005 0.867 0.003 0.891 0.003 0.892 0.004 0.950 0.000 0.782 0.004 Download
Estate fingerprints 0.873 0.005 0.767 0.004 0.820 0.000 0.830 0.000 0.900 0.000 0.643 0.005 Download
MACCS fingerprints 0.864 0.005 0.816 0.005 0.840 0.000 0.845 0.005 0.920 0.000 0.682 0.004 Download
Daylight fingerprints 0.878 0.004 0.782 0.004 0.830 0.000 0.840 0.000 0.861 0.003 0.670 0.000 Download
ECFP2 fingerprints 0.894 0.005 0.932 0.005 0.913 0.005 0.910 0.000 0.980 0.000 0.830 0.000 Download
ECFP4 fingerprints 0.910 0.000 0.974 0.004 0.942 0.004 0.940 0.000 0.990 0.000 0.890 0.000 Download
ECFP6 fingerprints 0.902 0.004 0.994 0.000 0.948 0.004 0.941 0.003 0.990 0.000 0.894 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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