Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
| Uniprot primary ID | P51681 |
| PDB ID | 1NE0 4MBS 1ND8 1OPN 2RLL 2RRS 2L87 1OPT 2MZX 1OPW |
| DrugBank ID | DB04835 |
| BioGrid ID | 107639 |
| GuidetoPHARMACOLOGY ID | 62 |
| PharmGKB ID | PA26170 |
| KEGG ID | hsa:1234 |
| DIP ID | DIP-5866N |
| STRING ID | 9606.ENSP00000292303 |
| IntAct ID | P51681 |
| DMDM | 1705896 |
| BRENDA | |
| Reactome | R-HSA-173107 R-HSA-380108 R-HSA-418594 |
| SignaLink | P51681 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1234 |
| BindingDB | P51681 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.911 | 0.003 | 0.867 | 0.000 | 0.889 | 0.003 | 0.890 | 0.000 | 0.950 | 0.000 | 0.771 | 0.003 | Download |
| Estate fingerprints | 0.900 | 0.000 | 0.760 | 0.000 | 0.830 | 0.000 | 0.840 | 0.000 | 0.900 | 0.000 | 0.670 | 0.000 | Download |
| MACCS fingerprints | 0.950 | 0.000 | 0.790 | 0.004 | 0.870 | 0.000 | 0.880 | 0.000 | 0.940 | 0.000 | 0.750 | 0.000 | Download |
| Daylight fingerprints | 0.851 | 0.003 | 0.921 | 0.000 | 0.886 | 0.005 | 0.880 | 0.000 | 0.930 | 0.000 | 0.770 | 0.000 | Download |
| ECFP2 fingerprints | 0.930 | 0.000 | 0.962 | 0.000 | 0.946 | 0.005 | 0.942 | 0.004 | 0.980 | 0.000 | 0.890 | 0.000 | Download |
| ECFP4 fingerprints | 0.920 | 0.000 | 0.990 | 0.000 | 0.955 | 0.005 | 0.950 | 0.000 | 0.987 | 0.005 | 0.910 | 0.000 | Download |
| ECFP6 fingerprints | 0.913 | 0.005 | 0.987 | 0.004 | 0.950 | 0.000 | 0.950 | 0.000 | 0.980 | 0.000 | 0.910 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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