Target name

P51681: C-C chemokine receptor type 5


  Protein function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

  Database links

Uniprot primary ID P51681
PDB ID 1NE0 4MBS 1ND8 1OPN 2RLL 2RRS 2L87 1OPT 2MZX 1OPW
DrugBank ID DB04835
BioGrid ID 107639
GuidetoPHARMACOLOGY ID 62
PharmGKB ID PA26170
KEGG ID hsa:1234
DIP ID DIP-5866N
STRING ID 9606.ENSP00000292303
IntAct ID P51681
DMDM 1705896
BRENDA
Reactome R-HSA-173107 R-HSA-380108 R-HSA-418594
SignaLink P51681
BioCyc
Entrez Gene (Gene ID) 1234
BindingDB P51681

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.911 0.003 0.867 0.000 0.889 0.003 0.890 0.000 0.950 0.000 0.771 0.003 Download
Estate fingerprints 0.900 0.000 0.760 0.000 0.830 0.000 0.840 0.000 0.900 0.000 0.670 0.000 Download
MACCS fingerprints 0.950 0.000 0.790 0.004 0.870 0.000 0.880 0.000 0.940 0.000 0.750 0.000 Download
Daylight fingerprints 0.851 0.003 0.921 0.000 0.886 0.005 0.880 0.000 0.930 0.000 0.770 0.000 Download
ECFP2 fingerprints 0.930 0.000 0.962 0.000 0.946 0.005 0.942 0.004 0.980 0.000 0.890 0.000 Download
ECFP4 fingerprints 0.920 0.000 0.990 0.000 0.955 0.005 0.950 0.000 0.987 0.005 0.910 0.000 Download
ECFP6 fingerprints 0.913 0.005 0.987 0.004 0.950 0.000 0.950 0.000 0.980 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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