Target name

P51685: C-C chemokine receptor type 8


  Protein function

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

  Database links

Uniprot primary ID P51685
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 65
PharmGKB ID PA26173
KEGG ID hsa:1237
DIP ID DIP-5836N
STRING ID 9606.ENSP00000326432
IntAct ID
DMDM 1707884
BRENDA
Reactome R-HSA-418594 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID) 1237
BindingDB P51685

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.970 0.000 0.962 0.007 0.966 0.005 0.966 0.005 0.990 0.000 0.935 0.007 Download
Estate fingerprints 0.941 0.009 0.803 0.005 0.872 0.006 0.879 0.003 0.940 0.000 0.749 0.010 Download
MACCS fingerprints 0.785 0.012 0.899 0.005 0.842 0.008 0.834 0.010 0.935 0.005 0.692 0.015 Download
Daylight fingerprints 0.723 0.016 0.995 0.000 0.859 0.009 0.838 0.011 0.990 0.000 0.754 0.013 Download
ECFP2 fingerprints 0.972 0.004 0.962 0.007 0.967 0.005 0.967 0.005 0.990 0.000 0.936 0.007 Download
ECFP4 fingerprints 0.979 0.003 0.997 0.004 0.988 0.004 0.988 0.004 0.990 0.000 0.969 0.003 Download
ECFP6 fingerprints 0.978 0.004 0.998 0.000 0.988 0.004 0.988 0.004 0.990 0.000 0.970 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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