Target name

P52333: Tyrosine-protein kinase JAK3


  Protein function

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

  Database links

Uniprot primary ID P52333
PDB ID 4RIO 4QT1 3ZC6 4HVH 4I6Q 3LXL 3ZEP 4QPS 4HVI 3PJC 1YVJ 3LXK 4HVG 4HVD
DrugBank ID DB08895
BioGrid ID 109921
GuidetoPHARMACOLOGY ID 2049
PharmGKB ID PA29990
KEGG ID hsa:3718
DIP ID DIP-274N
STRING ID 9606.ENSP00000391676
IntAct ID P52333
DMDM 50403745
BRENDA 2.7.10.2
Reactome R-HSA-1266695 R-HSA-114604 R-HSA-912526 R-HSA-451927 R-HSA-392451 R-HSA-5673001
SignaLink P52333
BioCyc
Entrez Gene (Gene ID) 3718
BindingDB P52333

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.807 0.005 0.893 0.000 0.850 0.000 0.840 0.000 0.930 0.000 0.700 0.000 Download
Estate fingerprints 0.800 0.000 0.780 0.000 0.790 0.000 0.790 0.000 0.874 0.005 0.577 0.005 Download
MACCS fingerprints 0.819 0.003 0.817 0.000 0.818 0.004 0.819 0.003 0.900 0.000 0.632 0.006 Download
Daylight fingerprints 0.733 0.005 0.843 0.003 0.788 0.004 0.777 0.005 0.870 0.000 0.579 0.006 Download
ECFP2 fingerprints 0.917 0.005 0.905 0.007 0.911 0.003 0.911 0.003 0.970 0.000 0.826 0.007 Download
ECFP4 fingerprints 0.900 0.000 0.980 0.003 0.940 0.000 0.935 0.005 0.980 0.000 0.877 0.005 Download
ECFP6 fingerprints 0.849 0.006 0.991 0.005 0.920 0.000 0.914 0.005 0.980 0.000 0.850 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn