Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.
| Uniprot primary ID | P53609 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 111250 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33233 |
| KEGG ID | hsa:5229 |
| DIP ID | |
| STRING ID | 9606.ENSP00000404676 |
| IntAct ID | P53609 |
| DMDM | 259016302 |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5229 |
| BindingDB | P53609 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.841 | 0.003 | 0.999 | 0.000 | 0.920 | 0.000 | 0.910 | 0.000 | 0.961 | 0.003 | 0.848 | 0.004 | Download |
| Estate fingerprints | 0.779 | 0.003 | 0.909 | 0.005 | 0.844 | 0.005 | 0.831 | 0.003 | 0.908 | 0.004 | 0.694 | 0.005 | Download |
| MACCS fingerprints | 0.828 | 0.004 | 0.870 | 0.004 | 0.849 | 0.003 | 0.847 | 0.005 | 0.890 | 0.000 | 0.697 | 0.005 | Download |
| Daylight fingerprints | 0.759 | 0.010 | 1.000 | 0.000 | 0.880 | 0.005 | 0.862 | 0.006 | 0.940 | 0.000 | 0.782 | 0.006 | Download |
| ECFP2 fingerprints | 0.892 | 0.004 | 0.986 | 0.000 | 0.939 | 0.003 | 0.934 | 0.005 | 0.990 | 0.000 | 0.879 | 0.003 | Download |
| ECFP4 fingerprints | 0.897 | 0.005 | 1.000 | 0.000 | 0.950 | 0.000 | 0.947 | 0.005 | 0.990 | 0.000 | 0.900 | 0.000 | Download |
| ECFP6 fingerprints | 0.871 | 0.003 | 0.993 | 0.000 | 0.932 | 0.004 | 0.930 | 0.000 | 0.989 | 0.003 | 0.879 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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