Target name

P53609: Geranylgeranyl transferase type-1 subunit beta


  Protein function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

  Database links

Uniprot primary ID P53609
PDB ID
DrugBank ID
BioGrid ID 111250
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33233
KEGG ID hsa:5229
DIP ID
STRING ID 9606.ENSP00000404676
IntAct ID P53609
DMDM 259016302
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 5229
BindingDB P53609

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.841 0.003 0.999 0.000 0.920 0.000 0.910 0.000 0.961 0.003 0.848 0.004 Download
Estate fingerprints 0.779 0.003 0.909 0.005 0.844 0.005 0.831 0.003 0.908 0.004 0.694 0.005 Download
MACCS fingerprints 0.828 0.004 0.870 0.004 0.849 0.003 0.847 0.005 0.890 0.000 0.697 0.005 Download
Daylight fingerprints 0.759 0.010 1.000 0.000 0.880 0.005 0.862 0.006 0.940 0.000 0.782 0.006 Download
ECFP2 fingerprints 0.892 0.004 0.986 0.000 0.939 0.003 0.934 0.005 0.990 0.000 0.879 0.003 Download
ECFP4 fingerprints 0.897 0.005 1.000 0.000 0.950 0.000 0.947 0.005 0.990 0.000 0.900 0.000 Download
ECFP6 fingerprints 0.871 0.003 0.993 0.000 0.932 0.004 0.930 0.000 0.989 0.003 0.879 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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