Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
Uniprot primary ID | P53779 |
PDB ID | 3OXI 3V6S 3V6R 2WAJ 2ZDT 3CGO 3TTI 3TTJ 3CGF 3FV8 4H36 3G9L 4W4Y 3G9N 2EXC 4WHZ 4W4W 4W4V 3PTG 3G90 3DA6 2ZDU 2OK1 4U79 3RTP 1JNK 4Y46 1PMN 4H3B 2R9S 4Z9L 3FI2 3FI3 4W4X 2P33 3OY1 1PMU 1PMV 2O0U 4H39 4Y5H 4KKH 4KKG 4KKE 2B1P 2O2U 3KVX |
DrugBank ID | |
BioGrid ID | 111588 |
GuidetoPHARMACOLOGY ID | 1498 |
PharmGKB ID | PA30617 |
KEGG ID | hsa:5602 |
DIP ID | DIP-1015N |
STRING ID | 9606.ENSP00000352157 |
IntAct ID | P53779 |
DMDM | 2507196 |
BRENDA | 2.7.11.24 |
Reactome | R-HSA-2871796 R-HSA-450321 R-HSA-450341 R-HSA-2559580 |
SignaLink | P53779 |
BioCyc | |
Entrez Gene (Gene ID) | 5602 |
BindingDB | P53779 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.828 | 0.004 | 0.830 | 0.005 | 0.829 | 0.003 | 0.828 | 0.004 | 0.900 | 0.000 | 0.655 | 0.005 | Download |
Estate fingerprints | 0.740 | 0.000 | 0.690 | 0.005 | 0.715 | 0.005 | 0.721 | 0.003 | 0.790 | 0.000 | 0.430 | 0.005 | Download |
MACCS fingerprints | 0.801 | 0.003 | 0.733 | 0.004 | 0.767 | 0.005 | 0.776 | 0.005 | 0.830 | 0.000 | 0.536 | 0.005 | Download |
Daylight fingerprints | 0.785 | 0.007 | 0.773 | 0.005 | 0.779 | 0.003 | 0.780 | 0.005 | 0.856 | 0.005 | 0.559 | 0.007 | Download |
ECFP2 fingerprints | 0.900 | 0.000 | 0.798 | 0.006 | 0.849 | 0.003 | 0.858 | 0.004 | 0.930 | 0.000 | 0.700 | 0.007 | Download |
ECFP4 fingerprints | 0.877 | 0.005 | 0.907 | 0.005 | 0.892 | 0.004 | 0.892 | 0.004 | 0.950 | 0.000 | 0.787 | 0.007 | Download |
ECFP6 fingerprints | 0.818 | 0.004 | 0.936 | 0.005 | 0.877 | 0.005 | 0.871 | 0.003 | 0.950 | 0.000 | 0.758 | 0.006 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn