Target name

P53779: Mitogen-activated protein kinase 10


  Protein function

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

  Database links

Uniprot primary ID P53779
PDB ID 3OXI 3V6S 3V6R 2WAJ 2ZDT 3CGO 3TTI 3TTJ 3CGF 3FV8 4H36 3G9L 4W4Y 3G9N 2EXC 4WHZ 4W4W 4W4V 3PTG 3G90 3DA6 2ZDU 2OK1 4U79 3RTP 1JNK 4Y46 1PMN 4H3B 2R9S 4Z9L 3FI2 3FI3 4W4X 2P33 3OY1 1PMU 1PMV 2O0U 4H39 4Y5H 4KKH 4KKG 4KKE 2B1P 2O2U 3KVX
DrugBank ID
BioGrid ID 111588
GuidetoPHARMACOLOGY ID 1498
PharmGKB ID PA30617
KEGG ID hsa:5602
DIP ID DIP-1015N
STRING ID 9606.ENSP00000352157
IntAct ID P53779
DMDM 2507196
BRENDA 2.7.11.24
Reactome R-HSA-2871796 R-HSA-450321 R-HSA-450341 R-HSA-2559580
SignaLink P53779
BioCyc
Entrez Gene (Gene ID) 5602
BindingDB P53779

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.828 0.004 0.830 0.005 0.829 0.003 0.828 0.004 0.900 0.000 0.655 0.005 Download
Estate fingerprints 0.740 0.000 0.690 0.005 0.715 0.005 0.721 0.003 0.790 0.000 0.430 0.005 Download
MACCS fingerprints 0.801 0.003 0.733 0.004 0.767 0.005 0.776 0.005 0.830 0.000 0.536 0.005 Download
Daylight fingerprints 0.785 0.007 0.773 0.005 0.779 0.003 0.780 0.005 0.856 0.005 0.559 0.007 Download
ECFP2 fingerprints 0.900 0.000 0.798 0.006 0.849 0.003 0.858 0.004 0.930 0.000 0.700 0.007 Download
ECFP4 fingerprints 0.877 0.005 0.907 0.005 0.892 0.004 0.892 0.004 0.950 0.000 0.787 0.007 Download
ECFP6 fingerprints 0.818 0.004 0.936 0.005 0.877 0.005 0.871 0.003 0.950 0.000 0.758 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn