Target name

P55157: Microsomal triglyceride transfer protein large subunit


  Protein function

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).

  Database links

Uniprot primary ID P55157
PDB ID
DrugBank ID DB01094 DB08827
BioGrid ID 110641
GuidetoPHARMACOLOGY ID
PharmGKB ID PA164742099
KEGG ID hsa:4547
DIP ID
STRING ID 9606.ENSP00000265517
IntAct ID
DMDM 1709167
BRENDA
Reactome R-HSA-174800
SignaLink
BioCyc
Entrez Gene (Gene ID) 4547
BindingDB P55157

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.964 0.005 Download
Estate fingerprints 0.908 0.008 0.872 0.007 0.890 0.007 0.892 0.004 0.970 0.000 0.782 0.010 Download
MACCS fingerprints 0.990 0.000 0.954 0.005 0.972 0.004 0.972 0.004 0.991 0.003 0.950 0.007 Download
Daylight fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP2 fingerprints 1.000 0.000 0.974 0.000 0.987 0.005 0.987 0.005 1.000 0.000 0.970 0.000 Download
ECFP4 fingerprints 1.000 0.000 0.980 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.990 0.000 Download
ECFP6 fingerprints 1.000 0.000 1.000 0.005 1.000 0.000 1.000 0.000 1.000 0.000 0.993 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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