TargetNet
  Target name

P55211: Caspase-9

  Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).

  Database links
Uniprot primary ID P55211
PDB ID 3YGS 1JXQ 3V3K 2AR9 3D9T 1NW9 4RHW
DrugBank ID
BioGrid ID 107292
GuidetoPHARMACOLOGY ID 1625
PharmGKB ID PA26094
KEGG ID hsa:842
DIP ID DIP-27625N
STRING ID 9606.ENSP00000330237
IntAct ID P55211
DMDM 28558771
BRENDA 3.4.22.62
Reactome R-HSA-111464 R-HSA-168638 R-HSA-418889 R-HSA-5674400 R-HSA-111463 R-HSA-198323 R-HSA-111458 R-HSA-111459
SignaLink
BioCyc
Entrez Gene (Gene ID) 842
BindingDB P55211
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.516 0.011 0.916 0.011 0.716 0.010 0.646 0.010 0.808 0.006 0.472 0.017 Download
Estate fingerprints 0.651 0.007 0.755 0.011 0.703 0.005 0.687 0.007 0.765 0.007 0.407 0.009 Download
MACCS fingerprints 0.725 0.007 0.791 0.005 0.758 0.006 0.750 0.007 0.826 0.005 0.516 0.010 Download
Daylight fingerprints 0.582 0.008 0.840 0.016 0.711 0.009 0.670 0.008 0.785 0.010 0.441 0.018 Download
ECFP2 fingerprints 0.819 0.009 0.785 0.008 0.802 0.006 0.804 0.005 0.894 0.005 0.604 0.010 Download
ECFP4 fingerprints 0.866 0.007 0.782 0.014 0.824 0.011 0.833 0.011 0.917 0.005 0.650 0.018 Download
ECFP6 fingerprints 0.826 0.018 0.824 0.005 0.825 0.007 0.824 0.010 0.914 0.005 0.650 0.018 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn