TargetNet
  Target name

P55212: Caspase-6

  Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

  Database links
Uniprot primary ID P55212
PDB ID 4EJF 3K7E 4N6G 3S70 3V6M 3V6L 3OD5 3NKF 3S8E 4N5D 4HVA 3P45 2WDP 1MI9 4FXO 4N7M 4N7J 3QNW 4NBK 4NBL 4NBN 3P4U 4IYR 3NR2
DrugBank ID
BioGrid ID 107289
GuidetoPHARMACOLOGY ID 1622
PharmGKB ID PA26090
KEGG ID hsa:839
DIP ID DIP-44649N
STRING ID 9606.ENSP00000265164
IntAct ID P55212
DMDM 26006981
BRENDA 3.4.22.59
Reactome R-HSA-111465 R-HSA-352238 R-HSA-264870
SignaLink
BioCyc
Entrez Gene (Gene ID) 839
BindingDB P55212
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.755 0.020 0.983 0.000 0.869 0.010 0.853 0.013 0.979 0.003 0.761 0.017 Download
Estate fingerprints 0.828 0.011 0.880 0.005 0.854 0.008 0.850 0.011 0.930 0.000 0.708 0.016 Download
MACCS fingerprints 0.685 0.005 0.895 0.008 0.790 0.005 0.766 0.005 0.930 0.000 0.593 0.008 Download
Daylight fingerprints 0.614 0.005 1.000 0.000 0.810 0.000 0.760 0.000 0.930 0.000 0.664 0.005 Download
ECFP2 fingerprints 0.910 0.005 0.994 0.004 0.952 0.004 0.950 0.005 0.990 0.000 0.906 0.008 Download
ECFP4 fingerprints 0.910 0.000 0.998 0.004 0.954 0.005 0.950 0.000 0.990 0.000 0.913 0.007 Download
ECFP6 fingerprints 0.881 0.003 1.000 0.000 0.941 0.003 0.936 0.005 0.989 0.003 0.887 0.007 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn