Target name

P55245: Epidermal growth factor receptor


  Protein function

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

  Database links

Uniprot primary ID P55245
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 9544.ENSMMUP00000029471
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P55245

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.740 0.000 0.918 0.000 0.829 0.003 0.810 0.000 0.920 0.000 0.660 0.000 Download
Estate fingerprints 0.778 0.004 0.782 0.000 0.780 0.000 0.780 0.000 0.860 0.000 0.558 0.004 Download
MACCS fingerprints 0.770 0.000 0.770 0.000 0.770 0.000 0.770 0.000 0.860 0.000 0.540 0.000 Download
Daylight fingerprints 0.680 0.000 0.960 0.000 0.820 0.000 0.790 0.000 0.900 0.000 0.670 0.000 Download
ECFP2 fingerprints 0.870 0.000 0.912 0.003 0.891 0.003 0.890 0.000 0.960 0.000 0.790 0.000 Download
ECFP4 fingerprints 0.822 0.004 0.978 0.000 0.900 0.000 0.890 0.000 0.960 0.000 0.810 0.000 Download
ECFP6 fingerprints 0.768 0.004 0.984 0.000 0.876 0.005 0.860 0.000 0.960 0.000 0.770 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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