Target name

P56450: Melanocortin receptor 4


  Protein function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

  Database links

Uniprot primary ID P56450
PDB ID
DrugBank ID
BioGrid ID 201341
GuidetoPHARMACOLOGY ID 285
PharmGKB ID
KEGG ID mmu:17202
DIP ID
STRING ID 10090.ENSMUSP00000054776
IntAct ID
DMDM
BRENDA
Reactome R-MMU-418555 R-MMU-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 17202
BindingDB P56450

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.960 0.000 0.980 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.934 0.005 Download
Estate fingerprints 0.964 0.005 0.964 0.000 0.964 0.005 0.964 0.005 0.990 0.000 0.924 0.005 Download
MACCS fingerprints 0.960 0.000 0.960 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.920 0.000 Download
Daylight fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP2 fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP4 fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP6 fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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