Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
| Uniprot primary ID | P56481 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 77 |
| PharmGKB ID | |
| KEGG ID | mmu:12426 |
| DIP ID | |
| STRING ID | 10090.ENSMUSP00000033189 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-MMU-416476 R-MMU-881907 R-MMU-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 12426 |
| BindingDB | P56481 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.929 | 0.006 | 0.973 | 0.003 | 0.951 | 0.003 | 0.949 | 0.003 | 0.983 | 0.005 | 0.901 | 0.006 | Download |
| Estate fingerprints | 0.812 | 0.006 | 0.848 | 0.009 | 0.830 | 0.005 | 0.827 | 0.005 | 0.910 | 0.000 | 0.658 | 0.009 | Download |
| MACCS fingerprints | 0.858 | 0.004 | 0.860 | 0.007 | 0.859 | 0.003 | 0.859 | 0.003 | 0.940 | 0.000 | 0.720 | 0.007 | Download |
| Daylight fingerprints | 0.942 | 0.004 | 0.980 | 0.005 | 0.961 | 0.003 | 0.959 | 0.003 | 0.977 | 0.005 | 0.917 | 0.007 | Download |
| ECFP2 fingerprints | 0.959 | 0.003 | 0.981 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.939 | 0.003 | Download |
| ECFP4 fingerprints | 0.949 | 0.006 | 0.993 | 0.000 | 0.971 | 0.003 | 0.970 | 0.000 | 0.990 | 0.000 | 0.944 | 0.005 | Download |
| ECFP6 fingerprints | 0.930 | 0.000 | 0.990 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.929 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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