Target name

P56481: Gastrin/cholecystokinin type B receptor


  Protein function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).

  Database links

Uniprot primary ID P56481
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 77
PharmGKB ID
KEGG ID mmu:12426
DIP ID
STRING ID 10090.ENSMUSP00000033189
IntAct ID
DMDM
BRENDA
Reactome R-MMU-416476 R-MMU-881907 R-MMU-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 12426
BindingDB P56481

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.929 0.006 0.973 0.003 0.951 0.003 0.949 0.003 0.983 0.005 0.901 0.006 Download
Estate fingerprints 0.812 0.006 0.848 0.009 0.830 0.005 0.827 0.005 0.910 0.000 0.658 0.009 Download
MACCS fingerprints 0.858 0.004 0.860 0.007 0.859 0.003 0.859 0.003 0.940 0.000 0.720 0.007 Download
Daylight fingerprints 0.942 0.004 0.980 0.005 0.961 0.003 0.959 0.003 0.977 0.005 0.917 0.007 Download
ECFP2 fingerprints 0.959 0.003 0.981 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download
ECFP4 fingerprints 0.949 0.006 0.993 0.000 0.971 0.003 0.970 0.000 0.990 0.000 0.944 0.005 Download
ECFP6 fingerprints 0.930 0.000 0.990 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.929 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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