The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| Uniprot primary ID | P56817 |
| PDB ID | 4B1E 4B1D 2QK5 2B8L 4J1K 3QI1 3WB4 1YM4 4B1C 1YM2 4J1I 4J1H 4FSE 4R5N 4J1E 4DJX 3DUY 3LNK 2B8V 4FSL 2VJ9 1M4H 2VKM 4B0Q 2VJ6 2VJ7 3TPP 4X2L 3TPR 4FM8 3DV1 3WB5 3OOZ 3INE 3QBH 3UQX 4J0V 3MSL 4GID 4ZPE 4J0Z 3UQR 3UQP 3UQW 3VV8 4WTU 3UQU 4J0T 4WY1 4ZPG 3DV5 |
| DrugBank ID | |
| BioGrid ID | 117154 |
| GuidetoPHARMACOLOGY ID | 2330 |
| PharmGKB ID | PA25232 |
| KEGG ID | |
| DIP ID | DIP-41388N |
| STRING ID | 9606.ENSP00000318585 |
| IntAct ID | P56817 |
| DMDM | 296434407 |
| BRENDA | 3.4.23.46 |
| Reactome | |
| SignaLink | |
| BioCyc | MetaCyc:ENSG00000160610-MONOMER |
| Entrez Gene (Gene ID) | 23621 |
| BindingDB | P56817 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.980 | 0.000 | 0.900 | 0.000 | Download |
| Estate fingerprints | 0.940 | 0.000 | 0.918 | 0.005 | 0.929 | 0.003 | 0.929 | 0.003 | 0.973 | 0.005 | 0.853 | 0.007 | Download |
| MACCS fingerprints | 0.927 | 0.012 | 0.991 | 0.000 | 0.959 | 0.003 | 0.959 | 0.003 | 0.980 | 0.000 | 0.923 | 0.007 | Download |
| Daylight fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.900 | 0.000 | Download |
| ECFP2 fingerprints | 0.921 | 0.003 | 0.999 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.989 | 0.003 | 0.921 | 0.003 | Download |
| ECFP4 fingerprints | 0.932 | 0.006 | 0.994 | 0.000 | 0.963 | 0.005 | 0.963 | 0.005 | 0.980 | 0.000 | 0.932 | 0.006 | Download |
| ECFP6 fingerprints | 0.939 | 0.006 | 0.999 | 0.000 | 0.969 | 0.006 | 0.969 | 0.006 | 0.988 | 0.004 | 0.941 | 0.007 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|