Target name

P56817: Beta-secretase 1


  Protein function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

  Database links

Uniprot primary ID P56817
PDB ID 4B1E 4B1D 2QK5 2B8L 4J1K 3QI1 3WB4 1YM4 4B1C 1YM2 4J1I 4J1H 4FSE 4R5N 4J1E 4DJX 3DUY 3LNK 2B8V 4FSL 2VJ9 1M4H 2VKM 4B0Q 2VJ6 2VJ7 3TPP 4X2L 3TPR 4FM8 3DV1 3WB5 3OOZ 3INE 3QBH 3UQX 4J0V 3MSL 4GID 4ZPE 4J0Z 3UQR 3UQP 3UQW 3VV8 4WTU 3UQU 4J0T 4WY1 4ZPG 3DV5
DrugBank ID
BioGrid ID 117154
GuidetoPHARMACOLOGY ID 2330
PharmGKB ID PA25232
KEGG ID
DIP ID DIP-41388N
STRING ID 9606.ENSP00000318585
IntAct ID P56817
DMDM 296434407
BRENDA 3.4.23.46
Reactome
SignaLink
BioCyc MetaCyc:ENSG00000160610-MONOMER
Entrez Gene (Gene ID) 23621
BindingDB P56817

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.900 0.000 Download
Estate fingerprints 0.940 0.000 0.918 0.005 0.929 0.003 0.929 0.003 0.973 0.005 0.853 0.007 Download
MACCS fingerprints 0.927 0.012 0.991 0.000 0.959 0.003 0.959 0.003 0.980 0.000 0.923 0.007 Download
Daylight fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 0.950 0.000 0.900 0.000 Download
ECFP2 fingerprints 0.921 0.003 0.999 0.000 0.960 0.000 0.960 0.000 0.989 0.003 0.921 0.003 Download
ECFP4 fingerprints 0.932 0.006 0.994 0.000 0.963 0.005 0.963 0.005 0.980 0.000 0.932 0.006 Download
ECFP6 fingerprints 0.939 0.006 0.999 0.000 0.969 0.006 0.969 0.006 0.988 0.004 0.941 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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