Target name

P60953: Cell division control protein 42 homolog


  Protein function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

  Database links

Uniprot primary ID P60953
PDB ID 1GRN 1AM4 1EES 2ASE 1NF3 1KZ7 4JS0 4YC7 1E0A 1DOA 2WMN 2WMO 4ITR 1AN0 2ODB 1AJE 2QRZ 3GCG 2KB0 1A4R 1CF4 2WM9 3QBV 1CEE 2DFK 1GZS 3VHL 4YDH 1KZG 1KI1 2NGR 4DID
DrugBank ID
BioGrid ID 107433
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26266
KEGG ID hsa:998
DIP ID DIP-31097N
STRING ID 9606.ENSP00000314458
IntAct ID P60953
DMDM 322510015
BRENDA
Reactome R-HSA-4420097 R-HSA-418885 R-HSA-416572 R-HSA-182971 R-HSA-2029482 R-HSA-416482 R-HSA-114604 R-HSA-5626467 R-HSA-3928662 R-HSA-5663220 R-HSA-194840 R-HSA-5625970 R-HSA-375170 R-HSA-5663213 R-HSA-389359 R-HSA-983231 R-HSA-428543 R-HSA-5687128 R-HSA-5627123
SignaLink P60953
BioCyc
Entrez Gene (Gene ID) 998
BindingDB P60953

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.669 0.003 0.989 0.000 0.829 0.003 0.795 0.005 0.865 0.005 0.686 0.005 Download
Estate fingerprints 0.739 0.014 0.795 0.013 0.767 0.008 0.761 0.007 0.845 0.005 0.536 0.015 Download
MACCS fingerprints 0.697 0.012 0.815 0.017 0.756 0.008 0.741 0.012 0.806 0.005 0.516 0.022 Download
Daylight fingerprints 0.642 0.011 0.998 0.005 0.820 0.007 0.781 0.009 0.865 0.005 0.687 0.012 Download
ECFP2 fingerprints 0.714 0.011 0.918 0.011 0.816 0.008 0.793 0.009 0.910 0.005 0.647 0.013 Download
ECFP4 fingerprints 0.792 0.009 0.960 0.010 0.876 0.007 0.865 0.008 0.944 0.005 0.766 0.015 Download
ECFP6 fingerprints 0.769 0.012 0.993 0.005 0.881 0.007 0.863 0.008 0.940 0.000 0.779 0.011 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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