The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
| Uniprot primary ID | P61073 |
| PDB ID | 4RWS 3OE0 2K03 3ODU 2K05 2K04 3OE6 3OE9 3OE8 |
| DrugBank ID | DB00452 DB06809 |
| BioGrid ID | 113607 |
| GuidetoPHARMACOLOGY ID | 71 |
| PharmGKB ID | PA27058 |
| KEGG ID | hsa:7852 |
| DIP ID | DIP-46290N;DIP-34773N |
| STRING ID | 9606.ENSP00000386884 |
| IntAct ID | P61073 |
| DMDM | 46577576 |
| BRENDA | |
| Reactome | R-HSA-173107 R-HSA-380108 R-HSA-418594 |
| SignaLink | P61073 |
| BioCyc | |
| Entrez Gene (Gene ID) | 7852 |
| BindingDB | P61073 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.959 | 0.003 | 0.919 | 0.006 | 0.939 | 0.006 | 0.940 | 0.005 | 0.960 | 0.000 | 0.881 | 0.010 | Download |
| Estate fingerprints | 0.849 | 0.006 | 0.839 | 0.009 | 0.844 | 0.005 | 0.848 | 0.004 | 0.939 | 0.003 | 0.693 | 0.009 | Download |
| MACCS fingerprints | 0.912 | 0.006 | 0.914 | 0.005 | 0.913 | 0.005 | 0.913 | 0.005 | 0.970 | 0.000 | 0.826 | 0.005 | Download |
| Daylight fingerprints | 0.701 | 0.003 | 0.959 | 0.000 | 0.830 | 0.000 | 0.803 | 0.005 | 0.935 | 0.005 | 0.681 | 0.003 | Download |
| ECFP2 fingerprints | 0.918 | 0.006 | 0.970 | 0.006 | 0.944 | 0.005 | 0.944 | 0.005 | 0.970 | 0.000 | 0.889 | 0.010 | Download |
| ECFP4 fingerprints | 0.918 | 0.004 | 0.978 | 0.000 | 0.948 | 0.004 | 0.940 | 0.000 | 0.979 | 0.003 | 0.890 | 0.000 | Download |
| ECFP6 fingerprints | 0.887 | 0.005 | 0.977 | 0.005 | 0.932 | 0.004 | 0.929 | 0.003 | 0.980 | 0.000 | 0.871 | 0.006 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|