Target name

P61073: C-X-C chemokine receptor type 4


  Protein function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

  Database links

Uniprot primary ID P61073
PDB ID 4RWS 3OE0 2K03 3ODU 2K05 2K04 3OE6 3OE9 3OE8
DrugBank ID DB00452 DB06809
BioGrid ID 113607
GuidetoPHARMACOLOGY ID 71
PharmGKB ID PA27058
KEGG ID hsa:7852
DIP ID DIP-46290N;DIP-34773N
STRING ID 9606.ENSP00000386884
IntAct ID P61073
DMDM 46577576
BRENDA
Reactome R-HSA-173107 R-HSA-380108 R-HSA-418594
SignaLink P61073
BioCyc
Entrez Gene (Gene ID) 7852
BindingDB P61073

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.959 0.003 0.919 0.006 0.939 0.006 0.940 0.005 0.960 0.000 0.881 0.010 Download
Estate fingerprints 0.849 0.006 0.839 0.009 0.844 0.005 0.848 0.004 0.939 0.003 0.693 0.009 Download
MACCS fingerprints 0.912 0.006 0.914 0.005 0.913 0.005 0.913 0.005 0.970 0.000 0.826 0.005 Download
Daylight fingerprints 0.701 0.003 0.959 0.000 0.830 0.000 0.803 0.005 0.935 0.005 0.681 0.003 Download
ECFP2 fingerprints 0.918 0.006 0.970 0.006 0.944 0.005 0.944 0.005 0.970 0.000 0.889 0.010 Download
ECFP4 fingerprints 0.918 0.004 0.978 0.000 0.948 0.004 0.940 0.000 0.979 0.003 0.890 0.000 Download
ECFP6 fingerprints 0.887 0.005 0.977 0.005 0.932 0.004 0.929 0.003 0.980 0.000 0.871 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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